Sangwan M, Chaudhary H, Mehan S, Khan Z, Bahauddin AA, Alrehaili BD, Elbadawy HM, Almikhlafi MA, Narula AS, Kalfin R, Wanas H. Effect of mitochondrial coenzyme-Q10 precursor solanesol in gentamicin-induced experimental nephrotoxicity: Evidence from restoration of ETC-complexes and histopathological alterations. Pharmacol Res Perspect. 2024 Oct;12(5):e70022. doi: 10.1002/prp2.70022. PMID: 39358913; PMCID: PMC11446958.
Kumar M, Mehan S, Kumar A, Sharma T, Khan Z, Tiwari A, Das Gupta G, Narula AS. Therapeutic efficacy of Genistein in activation of neuronal AC/cAMP/CREB/PKA and mitochondrial ETC-Complex pathways in experimental model of autism: Evidence from CSF, blood plasma and brain analysis. Brain Res. 2024 Oct 7:149251. doi: 10.1016/j.brainres.2024.149251. Epub ahead of print. PMID: 39384128.
Sethi P, Mehan S, Khan Z, Maurya PK, Kumar N, Kumar A, Tiwari A, Sharma T, Das Gupta G, Narula AS, Kalfin R. The SIRT-1/Nrf2/HO-1 axis: Guardians of neuronal health in neurological disorders. Behav Brain Res. 2024 Oct 4;476:115280. doi: 10.1016/j.bbr.2024.115280. Epub ahead of print. PMID: 39368713.
Sharma R, Mehan S, Khan Z, Das Gupta G, Narula AS. Therapeutic potential of oleanolic acid in modulation of PI3K/Akt/mTOR/STAT-3/GSK-3β signaling pathways and neuroprotection against methylmercury-induced neurodegeneration. Neurochem Int. 2024 Oct 3;180:105876. doi: 10.1016/j.neuint.2024.105876. Epub ahead of print. PMID: 39368746.
Sharma S, Mehan S, Khan Z, Tiwari A, Kumar A, Gupta GD, Narula AS, Kalfin R. Exploring the Neuroprotective Potential of Icariin through Modulation of Neural Pathways in the Treatment of Neurological Diseases. Curr Mol Med. 2024 Sep 26. doi: 10.2174/0115665240317650240924041923. Epub ahead of print. PMID: 39328135.
Ritika, Liao ZY, Chen PY, Rao NV, Mathew J, Sharma R, Grewal AS, Singh G, Mehan S, Liou JP, Pan CH, Nepali K. Rationally designed febuxostat-based hydroxamic acid and its pH-Responsive nanoformulation elicits anti-tumor activity. Eur J Med Chem. 2024 Sep 10;279:116866. doi: 10.1016/j.ejmech.2024.116866. Epub ahead of print. PMID: 39293244.
Dhiman A, Mehan S, Khan Z, Tiwari A, Gupta GD, Narula AS. Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives. Curr Gene Ther. 2024 Aug 30. doi: 10.2174/0115665232316708240828063527. Epub ahead of print. PMID: 39219434.
Sharma T, Mehan S, Tiwari A, Khan Z, Gupta GD, Narula AS. Targeting Oligodendrocyte Dynamics and Remyelination: Emerging Therapies and Personalized Approaches in Multiple Sclerosis Management. Curr Neurovasc Res. 2024 Aug 30. doi: 10.2174/0115672026336440240822063430. Epub ahead of print. PMID: 39219420.
Kumar A, Mehan S, Tiwari A, Khan Z, Gupta GD, Narula AS, Samant R. Magnesium (Mg2+): Essential Mineral for Neuronal Health: From Cellular Biochemistry to Cognitive Health and Behavior Regulation. Curr Pharm Des. 2024 Aug 27. doi: 10.2174/0113816128321466240816075041. Epub ahead of print. PMID: 39253923.
Kumar S, Mehan S, Khan Z, Das Gupta G, Narula AS. Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples. Mol Neurobiol. 2024 Aug;61(8):5161-5193. doi: 10.1007/s12035-023-03902-x. Epub 2024 Jan 3. PMID: 38170440.
Khan MS, Khan Z, Jabir NR, Mehan S, Suhail M, Zaidi SK, Zughaibi TA, Abid M, Tabrez S. Synthesis and Neurobehavioral Evaluation of a Potent Multitargeted Inhibitor for the Treatment of Alzheimer's Disease. Mol Neurobiol. 2024 Jul 15. doi: 10.1007/s12035-024-04351-w. Epub ahead of print. PMID: 39009798.
Khan Z, Mehan S, Gupta GD, Narula AS. Immune System Dysregulation in the Progression of Multiple Sclerosis: Molecular Insights and Therapeutic Implications. Neuroscience. Published online April 30, 2024. doi:10.1016/j.neuroscience.2024.04.004
Kumar N, Tyagi N, Mehan S, Singh AP. Formulation of Solid Lipid Nanoparticles Loaded with Rosiglitazone and Probiotic: Optimization and In-vitro Characterization. Recent Pat Nanotechnol. Published online January 15, 2024. doi:10.2174/0118722105268801231203144554
Khan Z, Mehan S, Saifi MA, Gupta GD, Narula AS, Kalfin R. Proton Pump Inhibitors and Cognitive Health: Review on Unraveling the Dementia Connection and Co-morbid Risks. Curr Alzheimer Res. Published online February 28, 2024. doi:10.2174/0115672050289946240223050737
Sharma N, Kurmi BD, Singh D, et al. Nanoparticles toxicity: an overview of its mechanism and plausible mitigation strategies. J Drug Target. Published online February 19, 2024. doi:10.1080/1061186X.2024.2316785 Dhiman P, Yadav N, Auti PS, et al. Discovery of thiazolidinedione-based pancreatic lipase inhibitors as anti-obesity agents: synthesis, in silico studies and pharmacological investigations. J Biomol Struct Dyn. Published online February 5, 2024. doi:10.1080/07391102.2024.2310799
Giri, A., Mehan, S., Khan, Z., Das Gupta, G., Narula, A. S., & Kalfin, R. (2024). Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders. Naunyn-Schmiedeberg's archives of pharmacology, 10.1007/s00210-023-02939-y. Advance online publication. https://doi.org/10.1007/s00210-023-02939-y
Sharma, S., Mehan, S., Khan, Z., Gupta, G. D., & Narula, A. S. (2024). Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations. Heliyon, 10(1), e24050. https://doi.org/10.1016/j.heliyon.2024.e24050
Kumar S, Mehan S, Khan Z, Das Gupta G, Narula AS. Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples. Mol Neurobiol. Published online January 3, 2024. doi:10.1007/s12035-023-03902-x
Prajapati A, Mehan S, Khan Z, Chhabra S, Das Gupta G. Purmorphamine, a Smo-Shh/Gli Activator, Promotes Sonic Hedgehog-Mediated Neurogenesis and Restores Behavioural and Neurochemical Deficits in Experimental Model of Multiple Sclerosis. Neurochem Res. Published online December 30, 2023. doi:10.1007/s11064-023-04082-9
iri A, Mehan S, Khan Z, Gupta GD, Narula AS. Melatonin-mediated IGF-1/GLP-1 activation in experimental OCD rats: Evidence from CSF, blood plasma, brain and in-silico investigations. Biochem Pharmacol. 2023;217:115831. doi:10.1016/j.bcp.2023.115831
Gumbar S, Bhardwaj S, Mehan S, et al. Renal mitochondrial restoration by gymnemic acid in gentamicin-mediated experimental nephrotoxicity: evidence from serum, kidney and histopathological alterations. Front Pharmacol. 2023;14:1218506. Published 2023 Jul 13. doi:10.3389/fphar.2023.1218506
Alexova, Ralitza & Alexandrova, Simona & Dragomanova, Stela & Kalfin, Reni & Solak, Ayten & Mehan, Sidharth & Petralia, Maria & Fagone, Paolo & Mangano, Katia & Nicoletti, Ferdinando & Tancheva, Lyubka. (2023). Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L.. Molecules. 28. 3772. 10.3390/molecules28093772.
Goldman L, Siddiqui EM, Khan A, Jahan S, Rehman MU, Mehan S, Sharma R, Budkin S, Kumar SN, Sahu A, Kumar M, Vaibhav K. Understanding Acquired Brain Injury: A Review. Biomedicines. 2022 Sep 2;10(9):2167. doi: 10.3390/biomedicines10092167. PMID: 36140268; PMCID: PMC9496189.
Kumar S, Mehan S, Narula AS. Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions. J Mol Med (Berl). 2023 Feb;101(1-2):9-49. doi: 10.1007/s00109-022-02272-6. Epub 2022 Dec 7. PMID: 36478124.
Alharbi M, Alshammari A, Kaur G, Kalra S, Mehan S, Suri M, Chhabra S, Kumar N, Alanazi WA, Alshanwani AR, Al-Ghamdi AH, Narula AS, Kalfin R. Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson's Rats: Preventing Mitochondrial, Motor and Histopathological Defects. Molecules. 2022 Nov 17;27(22):7951. doi: 10.3390/molecules27227951. PMID: 36432051; PMCID: PMC9695774.
Albekairi TH, Kamra A, Bhardwaj S, Mehan S, Giri A, Suri M, Alshammari A, Alharbi M, Alasmari AF, Narula AS, Kalfin R. Beta-Boswellic Acid Reverses 3-Nitropropionic Acid-Induced Molecular, Mitochondrial, and Histopathological Defects in Experimental Rat Model of Huntington's Disease. Biomedicines. 2022 Nov 9;10(11):2866. doi: 10.3390/biomedicines10112866. PMID: 36359390; PMCID: PMC9687177.
Bhalla S, Mehan S, Khan A, Rehman MU. Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions. Neurosci Biobehav Rev. 2022 Nov;142:104896. doi: 10.1016/j.neubiorev.2022.104896. Epub 2022 Oct 1. PMID: 36191807.
Kapoor T, Mehan S, Suri M, Sharma N, Kumar N, Narula AS, Alshammari A, Alasmari AF, Alharbi M, Assiri MA, Kalfin R. Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis. Cells. 2022 Sep 6;11(18):2771. doi: 10.3390/cells11182771. PMID: 36139346; PMCID: PMC9497421.
Rajkhowa B, Mehan S, Sethi P, Prajapati A, Suri M, Kumar S, Bhalla S, Narula AS, Alshammari A, Alharbi M, Alkahtani N, Alghamdi S, Kalfin R. Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder. Pharmaceuticals (Basel). 2022 Aug 2;15(8):959. doi: 10.3390/ph15080959. PMID: 36015107; PMCID: PMC9415079.
Upadhayay S, Mehan S, Prajapati A, Sethi P, Suri M, Zawawi A, Almashjary MN, Tabrez S. Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis. Genes (Basel). 2022 Jul 25;13(8):1324. doi: 10.3390/genes13081324. PMID: 35893061; PMCID: PMC9331916.
Shandilya A, Mehan S, Kumar S, Sethi P, Narula AS, Alshammari A, Alharbi M, Alasmari AF. Activation of IGF-1/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity. Molecules. 2022 Jun 16;27(12):3878. doi: 10.3390/molecules27123878. PMID: 35745001; PMCID: PMC9228431.
Mehan S, Arora N, Bhalla S, Khan A, U Rehman M, Alghamdi BS, Zughaibi TA, Ashraf GM. Involvement of Phytochemical-Encapsulated Nanoparticles' Interaction with Cellular Signalling in the Amelioration of Benign and Malignant Brain Tumours. Molecules. 2022 Jun 1;27(11):3561. doi: 10.3390/molecules27113561. PMID: 35684498; PMCID: PMC9182026.
Nabi SU, Khan A, Siddiqui EM, Rehman MU, Alshahrani S, Arafah A, Mehan S, Alsaffar RM, Alexiou A, Shen B. Mechanisms of Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope. Oxid Med Cell Longev. 2022 May 14;2022:4759963. doi: 10.1155/2022/4759963. PMID: 35607703; PMCID: PMC9124149.
Sahu R, Mehan S, Kumar S, Prajapati A, Alshammari A, Alharbi M, Assiri MA, Narula AS. Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats. Toxicol Rep. 2022 Apr 22;9:977-998. doi: 10.1016/j.toxrep.2022.04.023. PMID: 35783250; PMCID: PMC9247835.
Jadaun KS, Mehan S, Sharma A, Siddiqui EM, Kumar S, Alsuhaymi N. Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage. Curr Med Sci. 2022 Apr;42(2):249-266. doi: 10.1007/s11596-022-2496-x. Epub 2022 Jan 26. PMID: 35079960.
Mehan S, Bhalla S, Siddiqui EM, Sharma N, Shandilya A, Khan A. Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration. Degener Neurol Neuromuscul Dis. 2022 Mar 7;12:31-59. doi: 10.2147/DNND.S247153. PMID: 35300067; PMCID: PMC8921673.
Gupta R, Mehan S, Sethi P, Prajapati A, Alshammari A, Alharbi M, Al-Mazroua HA, Narula AS. Smo-Shh Agonist Purmorphamine Prevents Neurobehavioral and Neurochemical Defects in 8-OH-DPAT-Induced Experimental Model of Obsessive-Compulsive Disorder. Brain Sci. 2022 Mar 2;12(3):342. doi: 10.3390/brainsci12030342. PMID: 35326298; PMCID: PMC8946713.
Khera R, Mehan S, Bhalla S, Kumar S, Alshammari A, Alharbi M, Sadhu SS. Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism. Molecules. 2022 Jan 28;27(3):889. doi: 10.3390/molecules27030889. PMID: 35164154; PMCID: PMC8839522.
Jadaun KS, Mehan S, Sharma A, Siddiqui EM, Kumar S, Alsuhaymi N. Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage. Curr Med Sci. 2022 Jan 28. doi: 10.1007/s11596-022-2522-7. Epub ahead of print. PMID: 35099677.
Mehmood Siddiqui E, Mehan S, Upadhayay S, Khan A, Halawi M, Ahmed Halawi A, Alsaffar RM. Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage. Saudi J Biol Sci. 2021 Nov;28(11):6417-6431. doi: 10.1016/j.sjbs.2021.07.010. Epub 2021 Jul 10. PMID: 34764759; PMCID: PMC8568986.
Tiwari A, Khera R, Rahi S, Mehan S, Makeen HA, Khormi YH, Rehman MU, Khan A. Neuroprotective Effect of α-Mangostin in the Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats. Brain Sci. 2021 Feb 25;11(3):288. doi: 10.3390/brainsci11030288. PMID: 33669120; PMCID: PMC7996534.
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