Mehan Neuroscience

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Mehan Neuroscience

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    • Home
    • Publications
    • Research Group
    • Research Grants
    • Ongoing Research Projects
    • Techniques Established
    • Award & Honors
    • Research Positions
    • Collaboration
    • Patents
    • Alumni
    • Contact
  • Home
  • Publications
  • Research Group
  • Research Grants
  • Ongoing Research Projects
  • Techniques Established
  • Award & Honors
  • Research Positions
  • Collaboration
  • Patents
  • Alumni
  • Contact

Autism-rodent model established & validated

  •  Kumar M, Mehan S, Kumar A, Sharma T, Khan Z, Tiwari A, Das Gupta G, Narula AS. Therapeutic efficacy of Genistein in activation of neuronal AC/cAMP/CREB/PKA and mitochondrial ETC-Complex pathways in experimental model of autism: Evidence from CSF, blood plasma and brain analysis. Brain Res. 2024 Oct 7:149251. doi: 10.1016/j.brainres.2024.149251. Epub ahead of print. PMID: 39384128.  
  • Bhalla S, Mehan S. 4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats. Neuropeptides. 2022 Dec;96:102296. doi: 10.1016/j.npep.2022.102296. Epub 2022 Oct 20. PMID: 36307249.  
  •  Sharma A, Bhalla S, Mehan S. PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats. Metab Brain Dis. 2022 Aug;37(6):1909-1929. doi: 10.1007/s11011-022-01026-0. Epub 2022 Jun 10. PMID: 35687217.  
  •  Rahi S, Gupta R, Sharma A, Mehan S. Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism. Hum Exp Toxicol. 2021 Nov;40(11):1880-1898. doi: 10.1177/09603271211013456. Epub 2021 Apr 28. PMID: 33906504.  
  •  Tiwari A, Khera R, Rahi S, Mehan S, Makeen HA, Khormi YH, Rehman MU, Khan A. Neuroprotective Effect of α-Mangostin in the Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats. Brain Sci. 2021 Feb 25;11(3):288. doi: 10.3390/brainsci11030288. PMID: 33669120; PMCID: PMC7996534. 
  •  Mehan S, Rahi S, Tiwari A, Kapoor T, Rajdev K, Sharma R, Khera H, Kosey S, Kukkar U, Dudi R. Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mitochondrial dysfunction of autistic rats. Neural Regen Res. 2020 Jun;15(6):1140-1149. doi: 10.4103/1673-5374.270316. PMID: 31823895; PMCID: PMC7034277.  
  •  Sharma R, Rahi S, Mehan S. Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence. Toxicol Rep. 2019 Nov 5;6:1164-1175. doi: 10.1016/j.toxrep.2019.10.019. PMID: 31763180; PMCID: PMC6861559.  

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multiple sclerosis-rodent model established & validated

  •  Kumar S, Mehan S, Khan Z, Das Gupta G, Narula AS. Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples. Mol Neurobiol. 2024 Aug;61(8):5161-5193. doi: 10.1007/s12035-023-03902-x. Epub 2024 Jan 3. PMID: 38170440.
  • Chhabra S, Mehan S, Khan Z, Gupta GD, Narula AS. Matrine mediated neuroprotective potential in experimental multiple sclerosis: Evidence from CSF, blood markers, brain samples and in-silico investigations. J Neuroimmunol. 2023 Nov 15;384:578200. doi: 10.1016/j.jneuroim.2023.578200. Epub 2023 Sep 16. PMID: 37774554.  
  •  Prajapati A, Mehan S, Khan Z, Chhabra S, Das Gupta G. Purmorphamine, a Smo-Shh/Gli Activator, Promotes Sonic Hedgehog-Mediated Neurogenesis and Restores Behavioural and Neurochemical Deficits in Experimental Model of Multiple Sclerosis. Neurochem Res. 2024 Jun;49(6):1556-1576. doi: 10.1007/s11064-023-04082-9. Epub 2023 Dec 30. PMID: 38160216. 
  •  Kapoor T, Mehan S, Suri M, Sharma N, Kumar N, Narula AS, Alshammari A, Alasmari AF, Alharbi M, Assiri MA, Kalfin R. Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis. Cells. 2022 Sep 6;11(18):2771. doi: 10.3390/cells11182771. PMID: 36139346; PMCID: PMC9497421.    
  • Upadhayay S, Mehan S, Prajapati A, Sethi P, Suri M, Zawawi A, Almashjary MN, Tabrez S. Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis. Genes (Basel). 2022 Jul 25;13(8):1324. doi: 10.3390/genes13081324. PMID: 35893061; PMCID: PMC9331916. 
  •  Khera R, Mehan S, Bhalla S, Kumar S, Alshammari A, Alharbi M, Sadhu SS. Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism. Molecules. 2022 Jan 28;27(3):889. doi: 10.3390/molecules27030889. PMID: 35164154; PMCID: PMC8839522. 
  •  Kumar N, Sharma N, Khera R, Gupta R, Mehan S. Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain. Metab Brain Dis. 2021 Jun;36(5):911-925. doi: 10.1007/s11011-021-00691-x. Epub 2021 Feb 26. PMID: 33635478.   
  • Singh, Anshuman & Upadhayay, Shubham & Mehan, Sidharth. (2021). Inhibition of c-JNK/p38MAPK signaling pathway by Apigenin prevents neurobehavioral and neurochemical defects in ethidium bromide-induced experimental model of multiple sclerosis in rats: Evidence from CSF, blood plasma and brain samples. Phytomedicine Plus. 1. 100139. 10.1016/j.phyplu.2021.100139. 
  • Sharma, Nidhi & Upadhayay, Shubham & ., Ambika & Sahu, Rakesh & Singh, Anshuman & Rajkhowa, Bidisha & Mehan, Sidharth. (2021). Neuroprotection by solanesol against ethidium bromide-induced multiple sclerosis-like neurobehavioral, molecular, and neurochemical alterations in experimental rats. Phytomedicine Plus. 1. 100051. 10.1016/j.phyplu.2021.100051. 

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als-rodent model established & validated

  •  Sharma R, Mehan S, Khan Z, Das Gupta G, Narula AS. Therapeutic potential of oleanolic acid in modulation of PI3K/Akt/mTOR/STAT-3/GSK-3β signaling pathways and neuroprotection against methylmercury-induced neurodegeneration. Neurochem Int. 2024 Oct 3;180:105876. doi: 10.1016/j.neuint.2024.105876. Epub ahead of print. PMID: 39368746. 
  •  Sharma S, Mehan S, Khan Z, Gupta GD, Narula AS. Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations. Heliyon. 2024 Jan 6;10(1):e24050. doi: 10.1016/j.heliyon.2024.e24050. PMID: 38226245; PMCID: PMC10788811. 
  •  Shandilya A, Mehan S, Kumar S, Sethi P, Narula AS, Alshammari A, Alharbi M, Alasmari AF. Activation of IGF-1/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity. Molecules. 2022 Jun 16;27(12):3878. doi: 10.3390/molecules27123878. PMID: 35745001; PMCID: PMC9228431.
  • Sahu R, Mehan S, Kumar S, Prajapati A, Alshammari A, Alharbi M, Assiri MA, Narula AS. Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats. Toxicol Rep. 2022 Apr 22;9:977-998. doi: 10.1016/j.toxrep.2022.04.023. PMID: 35783250; PMCID: PMC9247835. 
  •  Yadav RK, Mehan S, Sahu R, Kumar S, Khan A, Makeen HA, Al Bratty M. Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221084276. doi: 10.1177/09603271221084276. PMID: 35373622. 
  •  Minj E, Upadhayay S, Mehan S. Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS. Neurochem Res. 2021 Nov;46(11):2867-2884. doi: 10.1007/s11064-021-03366-2. Epub 2021 Jun 1. PMID: 34075522.  
  • Mamtaj, Mohmmad & Minj, Elizabeth & Yadav, Rajeshwar & Mehan, Sidharth. (2020). Neuroprotective Potential of Adenyl Cyclase/cAMP/CREB and Mitochondrial CoQ10 Activator in Amyotrophic Lateral Sclerosis Rats. Current Bioactive Compounds. 16. 10.2174/1573407216999200723113054. 

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ocd & bd-rodent model established & validated

  •  Giri A, Mehan S, Khan Z, Gupta GD, Narula AS. Melatonin-mediated IGF-1/GLP-1 activation in experimental OCD rats: Evidence from CSF, blood plasma, brain and in-silico investigations. Biochem Pharmacol. 2023 Nov;217:115831. doi: 10.1016/j.bcp.2023.115831. Epub 2023 Sep 28. PMID: 37777162. 
  • Sethi P, Mehan S, Khan Z, Chhabra S. Acetyl-11-keto-beta boswellic acid(AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced by CSF, blood plasma and histopathological alterations. Neurotoxicology. 2023 Aug 5;98:61-85. doi: 10.1016/j.neuro.2023.08.001. Epub ahead of print. PMID: 37549874. 
  • Gupta R, Mehan S, Chhabra S, Giri A, Sherawat K. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotox Res. 2022 Dec;40(6):1718-1738. doi: 10.1007/s12640-022-00586-4. Epub 2022 Oct 22. PMID: 36272053. 
  •  Rajkhowa B, Mehan S, Sethi P, Prajapati A, Suri M, Kumar S, Bhalla S, Narula AS, Alshammari A, Alharbi M, Alkahtani N, Alghamdi S, Kalfin R. Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder. Pharmaceuticals (Basel). 2022 Aug 2;15(8):959. doi: 10.3390/ph15080959. PMID: 36015107; PMCID: PMC9415079. 

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ich-rodent model established & validated

  •  Rajdev K, Siddiqui EM, Jadaun KS, Mehan S. Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats. IBRO Rep. 2020 Apr 22;8:101-114. doi: 10.1016/j.ibror.2020.03.001. PMID: 32368686; PMCID: PMC7184235. 
  •  Jadaun KS, Mehan S, Sharma A, Siddiqui EM, Kumar S, Alsuhaymi N. Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage. Curr Med Sci. 2022 Apr;42(2):249-266. doi: 10.1007/s11596-022-2496-x. Epub 2022 Jan 26. PMID: 35079960. 
  •  Mehmood Siddiqui E, Mehan S, Upadhayay S, Khan A, Halawi M, Ahmed Halawi A, Alsaffar RM. Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage. Saudi J Biol Sci. 2021 Nov;28(11):6417-6431. doi: 10.1016/j.sjbs.2021.07.010. Epub 2021 Jul 10. PMID: 34764759; PMCID: PMC8568986. 

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